Postdoctoral Fellow (Cancer Drug Discovery) - Pathology Department - Bethesda, MD

Updated: April 9, 2020
Job ID: 215820
Status: Full-Time
Regular/Temporary: Regular
Location: Bethesda, MD, United States

Join the HJF Team!

HJF is seeking a Postdoctoral Fellow (Cancer Drug Discovery) to support the Pathology Department located at the Uniformed services University of Health Sciences (USUHS) in Bethesda, MD. HJF provides scientific, technical and programmatic support services to the Pathology Department at USUHS.

The incumbent will be responsible for initiating and carrying out research projects in collaboration with a research team. The purpose of this job to decipher the novel biomarkers in inflammation, cancer drug discovery specifically targeting antibodies, small molecules and CAR T therapy. The purpose is to test the efficacy of novel therapeutics in animal model and understand the underlying mechanics using advanced imaging, proteomics, metabolomics and molecular biology techniques. Below are three publication relevant to the work to be performed:

  1. Benti S, Tiwari PB, Goodlett DW, Daneshian L, Kern GB, Smith MD, Uren A, Chruszcz M, Shimizu LS, Upadhyay G. Small Molecule Binds with Lymphocyte Antigen 6K to Induce Cancer Cell Death. Cancers (Basel). 2020 Feb 22;12(2). pii: E509. doi: 10.3390/cancers12020509. PMC7072568
  2. Upadhyay G. Emerging Role of Lymphocyte Antigen-6 Family of Genes in Cancer and Immune Cells. Front Immunol. 2019 Apr 24;10:819. doi: 10.3389/fimmu.2019.00819. eCollection 2019. Review. PMID: 31068932
  3. AlHossiny M, Luo L, Frazier WR, Steiner N, Gusev Y, Kallakury B, Glasgow E, Creswell K, Madhavan S, Kumar R, Upadhyay G. Lymphocyte antigens 6 complex K/E-transforming growth factor-beta axis promotes breast cancer tumorigenesis. Cancer Research Published Online First April 11, 2016; doi: 10.1158/0008-5472.CAN-15-2654. PMID: 27197181

Responsibilities:

  1. Assists in designing, developing, executing, and implementing scientific research and/or development. (40%)
  2. Investigates the feasibility of applying a wide variety of scientific principles and theories to potential inventions and products. (15%)
  3. Performs specialized laboratory research utilizing experimental protocols which involves specialized procedures. (15%)
  4. Collects and handles samples and keeps detailed records of experiments. (10%)
  5. Assists with the preparation of data for presentations at scientific meetings and for publication in journals. (20%)
  6. May perform other duties and responsibilities as assigned or directed by the supervisor. This may include attendance of and participation in required training for role.

Required Knowledge, Skills and Abilities: Knowledge of appropriate scientific area; ability to analyze and interpret data. Ability to animal model for breast cancer/metastasis or pancreatic cancer, drug development, Microscopy, Flow cytometry, Biologics.

Minimum Education: Doctoral degree required. 

Minimum Experience/ Training Requirements: 0-5 years of relevant experience required. 

Work Environment: Set in a laboratory environment. 

Background/Security: Eligibility to obtain and maintain a Tier I investigation/Public Trust and a Common Access Card (CAC).

Employment with HJF is contingent upon successful completion of a background check, which may include, but is not limited to, contacting your professional references, verification of previous employment, addresses, education, and credentials, a criminal background check, drug screening, and a department of motor vehicle (DMV) check.

HJF is an equal opportunity and affirmative action employer.  All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or protected veteran status.

Any qualifications to be considered as equivalents, in lieu of stated minimums, require the prior approval of the Chief Human Resources Officer.

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