Postdoctoral Fellow - Military HIV Research Program - Silver Spring, MD

Updated: May 19, 2020
Job ID: 215633
Status: Full-Time
Regular/Temporary: Regular
Location: Silver Spring, MD, United States

Join the HJF Team!

HJF is seeking a Postdoctoral Fellow to support the Military HIV Research Program (MHRP) located at the Walter Reed Army Institute of Research (WRAIR) in Silver Spring, Maryland. HJF provides scientific, technical and programmatic support services to MHRP. 

The incumbent will be responsible for conducting research projects involving HIV-1 and SIV reservoirs of infected cells in animal models and humans. Incumbent will work independently to formulate research questions and design and execute experiments to test hypotheses pertaining to the mission of the Animal Models & Pathogenesis group and the US MHRP program. Specifically, he/she will investigate cell-associated virus during HIV/SIV infection. Research will focus on characterization of cells infected in vivo by flow cytometry and host and viral gene expression profiling. Model systems will include nonhuman primates and early acute HIV-1 infection in humans. State-of-the-art immunological and molecular biology techniques will be applied. The incumbent should be able to apply the scientific principles and concepts developed in these projects for potential inventions and products. 

The proposed work supports the mission of US MHRP and the warfighter. This research will help inform therapeutic strategies targeting replication-active viral reservoirs, which would significantly improve the capacity of the US Military to achieve sustained viral remission and eliminate the need for lifelong therapy among infected personnel.

Responsibilities: 

  1. Formulates experimental hypotheses, designs and implements experimental protocol.
  2. Develops necessary new technologies and protocols.
  3. Collects, processes and interprets experimental data.
  4. Trains and supervises technical staff and junior level staff scientists.
  5. Coordinates with other technical and professional staff.
  6. Must be proficient in immunologic and/or molecular biology techniques and up-to-date knowledge of relevant HIV-1 literature. 
  7. Performs data analysis, prepares graphical representation of data, makes oral presentations summarizing research progress, prepares manuscripts for publication in peer reviewed scientific journals, assists in the preparation of scientific reports for funded projects, presents research data at in-house meetings and at national and international scientific conferences.
  8. Provides collaborative assistance to other Research Scientists that require the incumbent's expertise.
  9. Performs specialized laboratory research utilizing experimental protocols, involving analytical techniques such as polychromatic flow cytometry, multiplex quantitative PCR and single-cell RNA-seq.
  10. Processes human and non-human primate tissue samples infected with SIV/HIV and performs live cell sorting in BSL-2+ laboratory.
  11. Maintains detailed records of experiments.
  12. Serves as an in-house consultant and takes lead on scientific collaborations both within and outside the institution as it pertains to USMHRP mission in consultation with supervisors.
  13. Attends all training and safety classes conducted by WRAIR and HJF.
  14. Completes other projects and duties as assigned.

Required Knowledge, Skills, and Abilities: Knowledge of HIV-1 virology, immunology, flow cytometry, PCR, and standard laboratory techniques is required. The incumbent should have excellent communication skills including the ability to efficiently prepare public seminars and research papers; grant-writing experience is optional. They should have a strong publication record as evidenced by first-author publications in virology (preferably HIV-1), immunology, or cell biology. They should have the ability to work in an independent capacity, be able to design experiments, troubleshoot technical procedures, and be capable of supervising junior staff.

Minimum Education/Training Requirements: Ph.D. in related scientific discipline.

Minimum Experience: 0-2 years of related post-doctoral research experience.

Physical Capabilities: Work involves long periods of standing, handling numerous chemicals and biological samples in the laboratory.

Supervisory Responsibilities/Controls: May provide guidance to laboratory staff and train junior staff members.

Work Environment: Laboratory environment; requires working with human and animal cells/cell lines, HIV-1, blood, and or bodily fluids; may require working long hours including evenings and weekends.

Background: Must have lived in the US 3 out of the past 5 years; eligible to pass a NACI background.

Employment with HJF is contingent upon successful completion of a background check, which may include, but is not limited to, contacting your professional references, verification of previous employment, addresses, education, and credentials, a criminal background check, drug screening, and a department of motor vehicle (DMV) check.  

HJF is an equal opportunity and affirmative action employer.  All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or protected veteran status.

Any qualifications to be considered as equivalents, in lieu of stated minimums, require the prior approval of the Chief Human Resources Officer.

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