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Join the HJF Team!
HJF is seeking a Postdoctoral Fellow - Informatics/Biomarker/Mouse Genetics/Cancer Immunology to support the lab of Dr. Geeta Upadhyay within the Department of Pathology located at Uniformed Services University of Health Sciences (USUHS) in Bethesda, MD. HJF provides scientific, technical and programmatic support services to USUHS.
The postdoctoral candidate will have the opportunity to conduct some of the research described in our newly funded R01 grant title “Role of Ly6K in TGF-beta and immune escape pathways of triple negative breast cancer”. Ly6K, a GPI anchored protein, is expressed in cancer tissue and is required for in vivo tumor progression. We have shown that Ly6K activates TGF-beta signaling, epithelial-to-mesenchymal transition and PD-L1 expression. We found that knockdown or pharmacological inhibition of Ly6K by small molecules binders, can significantly inhibit multiple distinct aspects of the biological activity of Ly6K. This proposal will be focused on determining the molecular basis of Ly6K action and Ly6K targeted therapeutics. In addition, they will be provided to develop new projects focused on drug resistance and drug development focused on Ly6E and other members of this family.
Required Knowledge, Skills, and Abilities:
Minimum Education/Training Requirements: PhD in a related scientific discipline.
Minimum Experience: 0-2 years of relevant experience.
Physical Capabilities: Long periods of standing and sitting; intricate work with hands; carrying of light and moderately heavy laboratory equipment.
Supervisory Responsibilities/Controls: May provide guidance to laboratory staff.
Work Environment: Laboratory environment; may involve working with biohazardous materials; may require working evenings and weekends.
Background: Eligibility to obtain a Common Access Card (CAC); eligibility to obtain and hold a Public Trust background.
Employment with HJF is contingent upon successful completion of a background check, which may include, but is not limited to, contacting your professional references, verification of previous employment, addresses, education, and credentials, a criminal background check, drug screening, and a department of motor vehicle (DMV) check.
HJF is an equal opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or protected veteran status.
Any qualifications to be considered as equivalents, in lieu of stated minimums, require the prior approval of the Chief Human Resources Officer.