Senior Scientist (Regenerative Medicine)

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Updated: Yesterday
Job ID: 213871
Status: Full-Time
Regular/Temporary: Regular
Location: Silver Spring, MD, United States

Join the HJF Team!

HJF is seeking a Senior Scientist to support the Regenerative Medicine Department located at the Regenerative Medicine Department (REGMED), Operational and Undersea Medicine Directorate (OUMD), NMRC, Silver Spring, MD. HJF provides scientific and program support services to NMRC.

The incumbent will help lead and manage multiple research teams in the study of two related areas: 1:  in vivo modeling to recapitulate combat-related injuries and sequela in both small and large animals and 2: the development of cellular techniques and/or pharmaceutical treatment regimens to mitigate trauma-induced injury, encourage tissue repair, and/or enable composite tissue transplantation after combat injuries (e.g. burn, blast, amputation, other). Solutions to these problems have been exceptionally elusive such that technical advances would have significant impact on military and civilian medicine.

ESSENTIAL JOB DUTIES:  (90% of time)

Technical Leadership (40%).  The incumbent will help lead and manage a multidisciplinary research team of government (military and civilian) Scientists and contract personnel in the conception, formulation, resourcing, execution, and defense of multidisciplinary research programs involving combat injury and regenerative medicine applications.   Thus, REGMED’s focus is on developing effective management and combined injury wound care strategies for treating injured Navy and Marine Corps Warfighters, in the acute, forward deployed setting, as well as during the regenerative medicine phase of definitive care.  Information is developed on the mechanisms of action after blast injury involving the plasticity of stem and/or progenitor cells to promote healing and resolution of injured tissues through immune modulatory or other mechanisms of action.  The program examines ways of both mitigating aberrant healing responses such as that seen in heterotopic ossification (HO), as well as strategies to stimulate tissue repair.  The program develops novel strategies and investigates the use of immune-modulatory agents (e.g., drugs, antibodies) for the prevention and treatment of other downstream complications of blast- and other types of combat injuries.

The incumbent will work in conjunction with the REGMED Department Head to help oversee the technical quality of all major scientific projects within REGMED, assesses progress and provides any necessary direction to other Scientists and Research Assistants.  The incumbent is also responsible for reviewing data and analyses from other REGMED investigators, focusing and strengthening their R&D efforts, and assisting them in identifying funding opportunities and preparing research proposals.  The incumbent fosters collaborative efforts between the REGMED Program and related efforts at federal laboratories, universities, and biotechnology organizations.

Staff Investigator (35%).  As an Investigator in the department, the incumbent actively participates in daily translational research work at the bench level.  He/she conducts physiology-based developmental research projects requiring a thorough foundation and seasoning in a formulation discipline. Projects require theoretical conceptualization and involve experimentation in areas which may have little or no standardized methodology. The incumbent designs an appropriate research methodology and conducts research without technical guidance. The incumbent’s research will focus on monitoring and defining the both the physiological and immunological response patterns to combat injury in both large and small animal models of polytraumatic injury involving hemorrhage, shock, and sepsis.

As an Investigator, the incumbent is responsible for conceptualizing, proposing, writing and submitting mission-related research proposals to secure funding; manage his/her project budgets in accordance with fiscal benchmarks and constraints; obtain IACUC, IRB, and/or DoN approval for proposals, protocols and clinical trials; and ensure the work proceeds satisfactorily along the scheduled time frames.  The incumbent prepares progress reports, publishes research results in peer-reviewed journals, and presents technical data at departmental, institutional, national and international meetings and forums.  The incumbent serves as a scientific expert and consultant in the area of basic biology and translational medicine to NMRC and outside investigators and establishes collaborative studies with other DoD, Non-DoD, academic, and corporate research laboratories with similar research interests.  He/she reviews and critiques research and development (R&D) areas when requested by higher authority; and develops, monitors, and evaluates contractual R&D performance as required.  The incumbent retains signature authority for the utilization of funds provided in proposals for which he/she is the Investigator.

Administrative (25%).  The incumbent will assist the REGMED Department Head in the day-to-day management and execution of all aspects of scientific research programs including planning, programming, budgeting, and logistics.  Manpower and personnel responsibilities include preparing staffing plans and staff development plans, managing staff awards and promotion nominations, and maintaining a team environment characterized by open communication, with clearly articulated assignments and schedules.  The incumbent also attends Command and OUMD leadership meetings and other intramural meetings, and works externally to integrate and coordinate REGMED research with other agencies and the private sector.  The incumbent assists in coordinating staff efforts to prepare polished program information (e.g., briefings, reports) for corporate and higher level offices, and reviews and submits all REGMED publications, presentations, and abstracts to the REGMED Department Head for approval

OTHER JOB DUTIES: (10% of time)

  1. Keep abreast with scientific literature and apply that knowledge appropriately to research projects.
  2. Follow and promote institutional, State and Federal safety instructions and regulations.
  3. Instruct medical students, residents and post-doctoral fellows in field of expertise.
  4. Mentor graduate level and summer students.

KNOWLEDGE REQUIRED BY THE POSITION

  • PhD, MD or PhD/MD degree in Physiology, Pathology, Biology/Systems Biology, Biochemistry, Molecular Biology,  Biomedical Engineering or equivalent. Minimum of 12 years post-doctoral experience in basic or translational research either in an academic and/or industry setting.
  • The incumbent must possess a practical knowledge of basic and applied research, including experimental design and methods, and must have demonstrated the ability to perform original and competent research.  He/she must have demonstrated the ability to co-manage a research program, including training of other Scientists, research associates, technicians, and support personnel; and management of necessary resources including budget, supplies, equipment and facilities.
  • The incumbent must have experience in small and large animal trauma models, wound healing immune cell biology (innate and adaptive immunity), inflammation, cytokine biology, and molecular biology and a working knowledge of stem cell biology, bone formation, wound healing and tissue repair mechanisms. He/she must have a consistent record of cutting edge research and / or clinically-related science as evidenced by first- or senior-authored publications in top-tier journals.  The incumbent must have expertise in in vivo animal modeling/testing and developing in vivo and/or in vitro assays to investigate immune function and possess knowledge of technologies commonly used to assess immune endpoints [e.g. multi-parameter flow cytometry and analysis, RT-PCR analysis, gene expression profiling, proteomic quantification and analysis, histology and immunohistochemistry and other immunoassay techniques/platforms (e.g. MLR, ELISA, Luminex, Western blot)].
  • The incumbent must have excellent oral and written communication skills, work well independently and as part of a team, and be able to work on multiple projects simultaneously to design experiments, interpret data, troubleshoot, and foresee next steps in the research process.
  • The incumbent should possess knowledge of grants and grant application processes; DoD, Office of Naval Research and Marine Corps Systems Command funding, organizational structure, and research policies; and other federal budget policies necessary to identify potential sponsors and relevant programs. The incumbent will need to demonstrate proficiency, effectiveness and growth in a fast-paced, dynamic, and fluid research environment.
  • The incumbent should possess a basic knowledge in management of personnel (military, government and contract) including recruitment, evaluation, counseling and disciplining.  He/she should have a demonstrated ability to build, focus, and guide a research team toward achieving technical program goals.
  • The incumbent should possess the demonstrated ability to effectively communicate (oral and written) in various settings, including national and international forums.

Minimum Education/Training Requirements:  This position requires a minimum of a Ph.D. and/or MD  Degree in research or clinical Physiology, Pathology, Biology/Systems Biology, Biochemistry, Molecular Biology, Biomedical Engineering or equivalent with strong written and verbal communication skills; exceptional organizational skills, attention to detail, and work quality; and a minimum of 12 years of research management experience with a track record of scientific accomplishment as evident by publication of peer-reviewed publications and intramural/extramural program funding.

Physical Capabilities: The incumbent may be required to stand or sit for long periods of time or bend from a standing position.  The incumbent will need to possess excellent hand-eye coordination and be able to carry light to moderate laboratory equipment while walking.

Supervisory Responsibilities: The incumbent may oversee the day-by-day activities of technicians, postdoctoral and graduate level or summer students. The incumbent will train junior personnel in the safe conduct of laboratory practices and procedures.

Work Environment: Office and technical bench environment (Molecular and Cellular Biology Laboratory). Advanced knowledge of Microsoft Office (Word, Excel, PowerPoint, Outlook) required.

Background: Ability to obtain and hold a Public Trust clearance to obtain a Common Access Card (CAC).

HJF is an equal opportunity and affirmative action employer.  All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or protected veteran status.

Any qualifications to be considered as equivalents, in lieu of stated minimums, require the prior approval of the Chief Human Resources Officer.

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